Document Detail

Mid-life onset of dietary restriction extends life and prolongs cognitive functioning.
MedLine Citation:
PMID:  8415944     Owner:  NLM     Status:  MEDLINE    
Fourteen-month-old C57BL/6 (NIA) mice were placed on a nutritionally complete diet providing 139.4 kcal/week. Over a 2-month period the food ration of experimental mice (AE) was reduced to 85 kcal/week, where it remained for the duration of the study. An aged control group (AC) continued with the higher calorie diet. At age 22 months, AC mice and half of the AE mice (AE22) were given a battery of behavioral tests. The remaining AE mice (AE25) were given the test battery at age 25 months. Also, a middle-aged control group (MC) was tested at age 13 months. Midlife onset caloric restriction (CR) increased longevity and preserved strength, coordination, and spontaneous alternation behavior, and altered responses to enclosed alleys. A spatial discrimination in the Morris water maze and a spatial delayed matching-to-sample water-escape task were insensitive to age and diet. The aged mice were adversely affected by testing.
L W Means; J L Higgins; T J Fernandez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  54     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-11-16     Completed Date:  1993-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
Department of Psychology, East Carolina University, Greenville, NC 27858-4353.
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MeSH Terms
Aging / physiology*
Arousal / physiology
Discrimination Learning / physiology*
Energy Intake / physiology
Escape Reaction / physiology
Food Deprivation / physiology*
Longevity / physiology*
Mental Recall / physiology*
Mice, Inbred C57BL
Motor Activity / physiology
Motor Skills / physiology*
Orientation / physiology
Problem Solving / physiology*
Reaction Time / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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