Document Detail

Mid-dermal elastolysis in a patient undergoing chronic hemodialysis.
MedLine Citation:
PMID:  19363907     Owner:  NLM     Status:  MEDLINE    
Mid-dermal elastolysis (MDE) is a rare acquired disorder of unknown etiology that typically presents as discrete patches of wrinkling over the trunk and arms or as perifollicular papules in the same distribution. The histopathologic finding of a bandlike loss of elastic tissue localized to the mid dermis is diagnostic. Our patient presented with atypical clinical features of urticarial papules and plaques that were histopathologically diagnostic of MDE. To our knowledge, the atypical presentation of MDE and association with hemodialysis have not been described. Furthermore, we believe matrix metalloproteinase (MMP) dysfunction to be involved in the pathogenesis of the disease.
Philip A Eaton; Alfred L Knable; Jeffrey P Callen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cutis     Volume:  83     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-14     Completed Date:  2009-05-28     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141-4     Citation Subset:  IM    
Division of Dermatology, Department of Medicine, University of Louisville, Kentucky, USA.
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MeSH Terms
Dermis / pathology*
Diagnosis, Differential
Elastic Tissue / pathology*
Middle Aged
Renal Dialysis / adverse effects*
Skin Diseases / diagnosis,  etiology*,  pathology

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