| Mid-aortic syndrome: long-term outcome of 36 children. | |
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MedLine Citation:
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PMID: 19603194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical characteristics and outcomes of children with mid-aortic syndrome (MAS) and the effectiveness of different therapeutic approaches in reducing hypertension are still debated. We conducted a single-centre retrospective review of the records of children with MAS over 30 years. Children with angiographic evidence of a narrowed abdominal aorta were included. Therapeutic approaches included medical management, percutaneous transluminal angioplasty and/or surgical intervention. Thirty-six children had presented at a median age of 2.7 years (10 days-10 years). Thirteen (36%) patients had associated syndromes, and 44% had been diagnosed with cerebrovascular disease. All patients had involvement of multiple arteries. The mortality rate was 8% after a median follow-up period of 4.5 (range 1.1-19.7) years. Among the children who survived, 90% had obtained a reduction in their blood pressure (BP). Of the patients, 76% had had a normal estimated glomerular filtration rate (eGFR) at the last follow-up examination. Seventeen percent (six of 36) had renal dysfunction at presentation. Although MAS is a severe and widespread disease, in most cases it can be effectively treated with a combination of medical, angioplasty and surgical interventions. |
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Authors:
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Albina Tummolo; Stephen D Marks; Marike Stadermann; Derek J Roebuck; Clare A McLaren; George Hamilton; Michael J Dillon; Kjell Tullus |
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Publication Detail:
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Type: Journal Article Date: 2009-07-15 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 24 ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-09-29 Completed Date: 2009-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 2225-32 Citation Subset: IM |
Affiliation:
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Department of Paediatric Nephrology, University of Bari, Italy. albinatummolo@yahoo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography Angioplasty, Balloon* Aorta / surgery* Aorta, Abdominal / radiography*, surgery* Aortic Diseases* / pathology, therapy Child Child, Preschool Female Follow-Up Studies Humans Male Retrospective Studies Syndrome Time Factors Treatment Outcome Vascular Surgical Procedures |
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