| Microwave radiation (2450 MHz) alters the endotoxin-induced hypothermic response of rats. | |
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MedLine Citation:
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PMID: 7284032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The parenteral administration of bacterial endotoxin to rats causes a hypothermia that is maximal after approximately 90 minutes. When endotoxin-injected rats were held in a controlled environment at 22 degree C and 50% relative humidity and exposed for 90 minutes to microwaves (2450 MHz, CW) at 1 mW/cm2, significant increases were observed in body temperature compared with endotoxin-treated, sham-irradiated rats. The magnitude of the response was related to power density (10 mW/cm2 greater than 5 mW/cm2 greater than 1 mW/cm2). Saline-injected rats exposed for 90 minutes at 5 mW/cm2 (specific absorption rate approximately 1.0 mW/g) showed no significant increase in body temperature compared with saline-injected, sham-irradiated rats. The hypothermia induced by endotoxin in rats was also found to be affected by ambient temperature alone. Increases in ambient temperature above 22 degree C in the absence of microwaves caused a concomitant increase in body temperature. This study reveals that subtle microwave heating is detectable in endotoxin-treated rats that have impaired thermoregulatory capability. These results indicate that the interpretation of microwave-induced biological effects observed in animals at comparable rates and levels of energy absorption should include a consideration of the thermogenic potential of microwave. |
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Authors:
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R J Smialowicz; K L Compton; M M Riddle; R R Rogers; P L Brugnolotti |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioelectromagnetics Volume: 1 ISSN: 0197-8462 ISO Abbreviation: Bioelectromagnetics Publication Date: 1980 |
Date Detail:
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Created Date: 1981-11-22 Completed Date: 1981-11-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008281 Medline TA: Bioelectromagnetics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 353-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization Animals Body Temperature / drug effects, radiation effects* Endotoxins / pharmacology* Lipopolysaccharides / pharmacology Male Microwaves Rats Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Lipopolysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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