Document Detail


Microwave assisted synthesis of some novel 2-pyrazoline derivatives as possible antimicrobial agents.
MedLine Citation:
PMID:  20210079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some new [3-(4-phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl](pyridine-4-yl)methanones and 3-substituted phenyl-5-substituted phenyl-4,5-dihydro-pyrazole-1-carbothioamides have been synthesized employing microwave techniques and evaluated for antimicrobial activity. Substituted acetophenones (1) were reacted with appropriately substituted benzaldehydes (2) in the presence of ethanol to furnish substituted chalcones (3a-f). These chalcones were further treated with isonicotinic acid hydrazide (INH) to afford substituted [3-(4-phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl](pyridine-4-yl)methanones (4a-f). Reaction of these chalcones with thiosemicarbazide yielded substituted 3,5-diphenyl-4,5-dihydro-1H-pyrazole-1-carbothioamides (5a-f). The structures of newly synthesized compounds (4a-f) and (5a-f) have been confirmed by suitable spectroscopic techniques such as IR and 1H NMR. All the compounds were screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and for antifungal activity against Candida albicans and Aspergillus niger The compounds exhibited moderate antibacterial and good antifungal activities. Compound 4b and 4d showed significant antifungal activity against A. niger and C. albicans, respectively.
Authors:
Rakesh Chawla; Ujjwal Sahoo; Anshu Arora; Prabodh Chander Sharma; Vijayaraj Radhakrishnan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta poloniae pharmaceutica     Volume:  67     ISSN:  0001-6837     ISO Abbreviation:  Acta Pol Pharm     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985167R     Medline TA:  Acta Pol Pharm     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  55-61     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Chemistry, S.D. College of Pharmacy, Barnala-148 101, India. rchawlapharma@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemical synthesis*,  pharmacology
Antifungal Agents / chemical synthesis*,  pharmacology
Disk Diffusion Antimicrobial Tests
Gram-Negative Bacteria / drug effects,  growth & development
Gram-Positive Bacteria / drug effects,  growth & development
Magnetic Resonance Spectroscopy
Microwaves*
Mitosporic Fungi / drug effects,  growth & development
Molecular Structure
Pyrazoles / chemical synthesis*,  pharmacology
Spectroscopy, Fourier Transform Infrared
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Pyrazoles

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