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Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas.
MedLine Citation:
PMID:  12182599     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
[reaction: see text] Microwave-assisted O-alkylations of several carboxylic acids have been performed with three different O-alkylisoureas. All reactions are significantly faster compared to conventionally heated reactions, while retaining high chemoselectivity. The combination of microwave technology with the use of the solid-supported isourea 3 enables the synthetic chemist to obtain the pure methyl esters starting from the corresponding acids in less than an hour.
Authors:
Stefano Crosignani; Peter D White; Bruno Linclau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Organic letters     Volume:  4     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-16     Completed Date:  2003-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2961-3     Citation Subset:  -    
Affiliation:
Combinatorial Centre of Excellence, Chemistry Department, University of Southampton, Southampton SO17 1BJ, United Kingdom.
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