| Microwave ablation: results with a 2.45-GHz applicator in ex vivo bovine and in vivo porcine liver. | |
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MedLine Citation:
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PMID: 16484351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To characterize the relationship between applied power and treatment duration in their effect on extent of coagulation produced with a 2.45-GHz microwave applicator in both an ex vivo and a perfused in vivo liver model. MATERIALS AND METHODS: All experimentation was approved by the Institute of Animal Care and Use Committee. Multiple tissue ablations were performed in ex vivo bovine liver (120 ablations) and in vivo porcine liver (45 ablations) with a 5.7-mm-diameter 2.45-GHz microwave applicator. The applied power was varied from 50 to 150 W (in 25-W increments ex vivo and 50-W increments in vivo), while treatment duration varied from 2 to 20 minutes (in eight time increments for ex vivo and five for in vivo liver). Three-dimensional contour maps of the resultant short- and long-axis coagulation diameters were constructed to identify the optimal parameters to achieve maximum coagulation in both ex vivo and in vivo models. Multivariate analysis was performed to characterize the relationship between applied power and treatment duration. RESULTS: Power and treatment duration were both associated with coagulation diameter in a sigmoidal fashion (ex vivo, R(2) = 0.78; in vivo, R(2) = 0.74). For ex vivo liver, the maximum short-axis coagulation diameter (7.6 cm +/- 0.2 [standard deviation] by 12.3 cm +/- 0.8) was achieved at greatest power (150 W) and duration (20 minutes). In vivo studies revealed a sigmoidal relationship between duration and coagulation size, with a relative plateau in coagulation size achieved within 8 minutes duration at all power levels. After 8 minutes of treatment at 150 W, the mean short-axis coagulation diameter for in vivo liver was 5.7 cm +/- 0.2 by 6.5 cm +/- 1.7, which was significantly larger than the corresponding result for ex vivo liver (P < .05). CONCLUSION: Large zones of ablation can be achieved with the 2.45-GHz microwave applicator used by the authors. For higher-power ablations, larger zones of coagulation were achieved for in vivo liver than for ex vivo liver with short energy applications, a finding previously not seen with other ablation devices, to the authors' knowledge. |
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Authors:
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Andrew U Hines-Peralta; Nadeer Pirani; Peter Clegg; Nigel Cronin; Thomas P Ryan; Zhenjun Liu; S Nahum Goldberg |
Publication Detail:
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Type: In Vitro; Journal Article Date: 2006-02-16 |
Journal Detail:
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Title: Radiology Volume: 239 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-28 Completed Date: 2006-05-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 94-102 Citation Subset: AIM; IM |
Copyright Information:
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(c) RSNA, 2006. |
Affiliation:
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Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Rd, WCC 308B, Boston, MA 02215, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Diathermy / instrumentation Equipment Design Liver / surgery* Microwaves / therapeutic use* Swine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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