| A Microwave-Assisted Synthesis of (S)-N-Protected Homoserine γ-Lactones from l-Aspartic Acid. | |
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MedLine Citation:
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PMID: 21770382 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A three-pot preparation of (S)-N-protected homoserine γ-lactones is presented. Conversion of N-protected l-aspartic acid to an oxazolidinone is followed by selective reduction/acid-catalyzed cyclization to deliver the lactones. Microwave irradiation proved valuable for improving the latter reaction steps in some cases. |
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Authors:
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Suneel P Singh; Alex Michaelides; A Rod Merrill; Adrian L Schwan |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-19 |
Journal Detail:
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Title: The Journal of organic chemistry Volume: - ISSN: 1520-6904 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry and ‡Department of Molecular and Cellular Biology, University of Guelph , Guelph, Ontario, Canada N1G 2W1. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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