Document Detail


Microvolt T-Wave Alternans in Short QT Syndrome.
MedLine Citation:
PMID:  22897428     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: T-wave alternans (TWA) is an accepted marker of risk for malignant ventricular arrhythmias, for which prognosis value has been established in different populations. Short QT syndrome (SQTS) is a very rare primary electrical disease carrying the risk of ventricular fibrillation. TWA in SQTS has not been evaluated yet. Methods: Thirteen patients with SQTS (QT = 308 ± 16 ms, QTc = 329 ± 10 ms, heart rate = 69 ± 8 beats/min) underwent microvolt TWA measurement using spectral analysis. TWA testing was performed using Heartwave II (Cambridge Heart™, Inc., Bedford, MA, USA) during bicycle exercice and classified as negative, positive, or indeterminate according to the published standards for clinical interpretation. Results: Twelve patients were male (mean age 23 ± 5 years). Five were asymptomatic, three presented with aborted sudden cardiac death, and five with unexplained syncope. Six patients belonged to two unrelated families, while familial cases of SQTS were present for two other patients. A familial history of sudden death (SD) was present for seven patients. Ventricular fibrillation was inducible in three patients. Four patients were implanted with an implantable cardioverter-defibrillator and one presented with polymorphic ventricular tachycardia during follow-up. TWA was negative in each but one patient (indeterminate). Maximal negative heart rate was 118 ± 12 beats/min. Patients with previous SD displayed significant shorter QT and higher resting heart rate compared to the remaining cases. Conclusions: TWA testing is negative in 12 of 13 SQTS patients, even in the symptomatic or inducible ones. Measurement of TWA using conventional protocol and criteria for risk stratification in SQTS seems therefore useless. (PACE 2012;00:1-7).
Authors:
Philippe Maury; Fabrice Extramiana; Carla Giustetto; Cristelle Cardin; Anne Rollin; Alexandre Duparc; Pierre Mondoly; Isabelle Denjoy; Marc Delay; Anne Messali; Antoine Leenhardt; Daniele Marangoni
Related Documents :
8923368 - Clinical manifestations of temporal arteritis: a report from israel.
16515998 - Penile carcinoma in patients with genital lichen sclerosus: a multicenter survey.
22560918 - Outcome of patients with normal and decreased heart rate variability after coronary art...
22046088 - Role of high definition colonoscopy in colorectal adenomatous polyp detection.
19726938 - Neuro-ophthalmologic features of spinocerebellar ataxia type 7.
6191008 - Hla antigens and progression of multiple sclerosis. part ii.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-16
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  -     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2012, The Authors. Journal compilation ©2012 Wiley Periodicals, Inc.
Affiliation:
University Hospital Rangueil, Toulouse, France University Hospital Bichat Paris, France Division of Cardiology, University of Turin, San Giovanni Battista Hospital, Turin, Italy Cambridge Heart, Inc., Verona, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Attenuation of foot pressure during running on four different surfaces: asphalt, concrete, rubber, a...
Next Document:  A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 e...