Document Detail

Microvessels in chronic total occlusions: pathways for successful guidewire crossing?
MedLine Citation:
PMID:  16336422     Owner:  NLM     Status:  MEDLINE    
Arterial chronic total occlusions (CTO) are a common and clinically relevant problem in patients with coronary artery disease. Percutaneous coronary intervention (PCI) success rates in a wide range of CTO are low, primarily due to inability of guidewire crossing. The pathophysiology of CTO is poorly understood and limits our ability to introduce innovative therapies. Recent studies from our laboratory have suggested that microvessel formation within arterial CTO is a complex process with temporal and regional differences. Moreover, there is evidence from pilot studies that the presence of either microvessels or the particular extracellular matrix environment in the adjacent perivascular tissue can facilitate guidewire crossing and successful PCI. Currently, studies are underway in our experimental CTO model to delineate the pathophysiology of microvessel formation in CTO and its potential role in PCI.
Bradley H Strauss; Amit Segev; Graham A Wright; Beiping Qiang; Nigel Munce; Kevan J T Anderson; General Leung; Alexander J Dick; Renu Virmani; Jagdish Butany
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  18     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  425-36     Citation Subset:  IM    
Copyright Information:
(J Interven Cardiol 2005;18:425-436).
The Roy and Ann Foss Cardiovascular Research Program, Terrence Donnelly Heart Center, St. Michael's Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Chronic Disease
Coronary Stenosis / diagnosis,  physiopathology,  therapy*
Heart Catheterization / instrumentation*,  methods
Neovascularization, Pathologic
Thromboembolism / diagnosis,  physiopathology*

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