| Microvasculopathic neuromuscular diseases: lessons from hypoxia-inducible factors. | |
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MedLine Citation:
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PMID: 20122829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dermatomyositis and vasculitic neuropathies are disorders with immune mediated ischemic injuries. Cellular responses to hypoxia include the hypoxia-inducible factor-1 (HIF-1)-induced transcription of genes involved in angiogenesis. To study their possible roles in those disorders, the immunohistochemical expression of HIF-1alpha, HIF-1beta, HIF-2alpha, vascular endothelial growth factor (VEGF), VEGF-receptor (VEGF-R) and erythropoietin-receptor was investigated. Cases of normal nerves, diabetic neuropathy, normal muscles, polymyositis and inclusion-body-myositis served as controls. The latter were chosen because they represent comparable inflammatory disorders, however, in these ischemia/hypoxia is not supposed to play such a prominent pathogenetic role. Hypoxia-related proteins were not detected in normal controls. In polymyositis and inclusion-body-myositis, there was VEGF-R-expression in muscle fibers and HIF-2alpha reactivity in endothelial cells. In dermatomyositis, HIF-1alpha and HIF-1beta were found in endothelial cells, whereas HIF-2alpha, erythropoietin-receptor, VEGF and VEGF-R additionally were observed in muscle fibers. In vasculitic and diabetic neuropathies, a variable focal expression of hypoxia-inducible factors, VEGF, VEGF-R and erythropoietin-receptor was seen in vessels. These observations suggest that the upregulation of hypoxia-related proteins may represent an adaptation mechanism of neuromuscular tissues to immune mediated deprivation of the blood supply. |
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Authors:
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Stefan Probst-Cousin; Bernhard Neund?rfer; Dieter Heuss |
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Publication Detail:
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Type: Journal Article Date: 2010-02-01 |
Journal Detail:
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Title: Neuromuscular disorders : NMD Volume: 20 ISSN: 1873-2364 ISO Abbreviation: Neuromuscul. Disord. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-17 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111470 Medline TA: Neuromuscul Disord Country: England |
Other Details:
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Languages: eng Pagination: 192-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurology, Klinikum Bremen-Ost, Bremen, Germany. stefan.probst@klinikum-bremen-ost.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angiogenesis Inducing Agents / metabolism Basic Helix-Loop-Helix Transcription Factors / metabolism Ephrin-B2 / metabolism Female Humans Hypoxia-Inducible Factor 1 / genetics, metabolism* Male Microvessels / metabolism*, pathology Middle Aged Neovascularization, Pathologic / etiology, metabolism Neuromuscular Diseases / complications, metabolism*, pathology* Proteins / metabolism Receptors, Erythropoietin / metabolism Receptors, Vascular Endothelial Growth Factor / metabolism Up-Regulation / physiology Vascular Endothelial Growth Factor A / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inducing Agents; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Ephrin-B2; 0/Hypoxia-Inducible Factor 1; 0/Proteins; 0/Receptors, Erythropoietin; 0/Vascular Endothelial Growth Factor A; 0/endothelial PAS domain-containing protein 1; 0/oxygen-regulated proteins; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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