| Microvascular thrombosis and multiple organ dysfunction syndrome. | |
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MedLine Citation:
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PMID: 20083912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper will review the involvement of disseminated intravascular coagulation-induced microvascular thrombosis in the pathogenesis of multiple organ dysfunction syndrome and the interaction between disseminated intravascular coagulation and systemic inflammatory response syndrome in critically ill patients. The published literature on clinical and experimental studies are the data sources of the study. Histologic evidence of microvascular thrombosis and tissue injury in disseminated intravascular coagulation has been reported in clinical, experimental, and autopsy findings. Proinflammatory cytokine-evoked neutrophil-endothelial activation and interplay between inflammation and coagulation through protease-activated receptors contribute to enhanced microvascular fibrin deposition in organs. In a clinical setting, systemic inflammatory response syndrome and disseminated intravascular coagulation synergistically play pivotal roles in the development of multiple organ dysfunction syndrome and in the poor prognosis of critical illness. Disseminated intravascular coagulation contributes to microvascular thrombosis and subsequent multiple organ dysfunction syndrome. Recent knowledge on the relationship between disseminated intravascular coagulation and systemic inflammatory response syndrome gives further insight into the pathogenic mechanisms of multiple organ dysfunction syndrome in critically ill patients. |
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Authors:
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Satoshi Gando |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical care medicine Volume: 38 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-19 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: S35-42 Citation Subset: AIM; IM |
Affiliation:
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Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan. gando@med.hokudai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ADAM Proteins
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physiology Acute Lung Injury / etiology Animals Cerebrovascular Disorders / etiology Cytokines / physiology Disseminated Intravascular Coagulation / complications Endothelium, Vascular / physiology HMGB1 Protein / physiology Humans Kidney Failure, Acute / etiology Liver Diseases / etiology Microvessels / physiopathology Multiple Organ Failure / etiology* Neutrophils / physiology Receptors, Proteinase-Activated / physiology Thrombosis / complications* Thrombotic Microangiopathies / complications |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/HMGB1 Protein; 0/Receptors, Proteinase-Activated; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human |
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