| Microvascular thrombosis in pediatric multiple organ failure: Is it a therapeutic target? | |
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MedLine Citation:
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PMID: 12793940 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To discuss the current rationale for the use of specific and nonspecific therapies for thrombotic microangiopathy in thrombocytopenia-associated pediatric multiple organ failure syndromes. Methods: Pertinent PubMed and MEDLINE citations and proceedings of recent critical care meeting presentations were reviewed. RESULTS: Critical care clinicians have reported using antithrombin III concentrate, protein C concentrate, activated protein C, prostacyclin and its analogues, heparin, tissue factor pathway inhibitor concentrate, plasma infusion, plasma exchange, whole blood exchange, pentoxifylline, tissue plasminogen activator, urokinase, and streptokinase with perceived therapeutic benefits in patients with thrombocytopenia-associated multiple organ failure, including those with thrombotic thrombocytopenic purpura/hemolytic uremic syndrome, disseminated intravascular coagulation syndrome, and secondary thrombotic microangiopathy syndrome without prolonged prothrombin time/activated partial thromboplastin time. CONCLUSION: Assuming that underlying disease is remediable, a consensus has developed that thrombotic microangiopathy is a therapeutic target in children with thrombocytopenia-associated multiple organ failure syndromes. Studies are warranted to delineate efficacious use of specific and nonspecific therapies to prevent and reverse thrombotic microangiopathy in these patients. |
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Authors:
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Trung Nguyen; Mark Hall; Yong Han; Melinda Fiedor; Andrea Hasset; Ileana Lopez-Plaza; Scott Watson; Lucy Lum; Joseph A. Carcillo |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies Volume: 2 ISSN: - ISO Abbreviation: Pediatr Crit Care Med Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2003-Jun-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954653 Medline TA: Pediatr Crit Care Med Country: - |
Other Details:
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Languages: ENG Pagination: 187-196 Citation Subset: - |
Affiliation:
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Departments of Critical Care Medicine (Drs. Nguyen, Hall, Han, Fiedor, Watson, and Carcillo) and the Pathology (Dr. Lopez-Plaza), University of Pittsburgh School of Medicine, Pittsburgh, PA; the Institute for Transfusion Medicine, Pittsburgh, PA (Dr. Hasset); and the Department of Pediatrics, University of Malaya, Kuala Lampur, Indonesia (Dr. Lum). E-mail: CarcilloJA@anes.upmc.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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