| Microvascular testicular blood flow as evaluated by laser Doppler flowmetry after the surgical induction of varicocele. | |
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MedLine Citation:
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PMID: 11339645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted to evaluate the changes in microvascular testicular blood flow (microvascular TBF), which may be associated with varicocele. The pathology was developed through partial ligation of left renal vein in 4 groups of rats. Controls of each group underwent sham surgery. It was observed that microvascular TBF dropped and its vasomotion became inhibited once the left renal vein was partially ligated as studied by laser Doppler flowmetry (LDF). Four to five minutes later, blood flow rose to the pretreatment level and that of controls. Vasomotion reappeared with a uniform frequency and amplitude. At different periods of varicocele bearing (1, 3, 6, and 14 weeks) microvascular TBF was reevaluated. Vasomotion appeared intact without any abnormalities in the 4 groups. To examine the response of testicular microvasculature after surgical creation of the varicocele to pharmacological stimulation another group of animals received human chorionic gonadotropin (hCG) treatment 6 weeks after varicocele creation. Vasomotion was inhibited in these animals. In conclusion, LDF is a suitable tool to evaluate microvascular TBF in vivo. It can detect acute changes in blood flow that may happen at surgical induction of varicocele. In addition, the vasculature of the testis with a surgically induced varicocele can still respond to hCG stimulation. |
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Authors:
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N Salama; A Bergh; J E Damber |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Archives of andrology Volume: 46 ISSN: 0148-5016 ISO Abbreviation: Arch. Androl. Publication Date: 2001 May-Jun |
Date Detail:
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Created Date: 2001-05-07 Completed Date: 2001-08-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7806755 Medline TA: Arch Androl Country: England |
Other Details:
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Languages: eng Pagination: 197-204 Citation Subset: IM |
Affiliation:
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Department of Urology and Andrology, Umeå University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillaries Chorionic Gonadotropin / pharmacology Laser-Doppler Flowmetry* Male Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Spermatogenesis Testis / blood supply*, physiopathology, surgery Varicocele / pathology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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