| Microvascular system of the lumbar dorsal root ganglia in rats. Part II: neurogenic control of intraganglionic blood flow. | |
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MedLine Citation:
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PMID: 20121357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECT: The dorsal root ganglion (DRG) should not be overlooked when considering the mechanism of low-back pain and sciatica, so it is important to understand the morphological features of the vascular system supplying the DRG. However, the neurogenic control of intraganglionic blood flow has received little attention in the past. The authors used an immunohistochemical technique to investigate the presence and distribution of autonomic and sensory nerves in blood vessels of the DRG. METHODS: Ten Wistar rats were used. To investigate the mechanism of vasomotion on the lumbar DRG, the authors used immunohistochemical methods. Sections were incubated overnight with antisera to tyrosine hydroxylase (TH), aromatic L-amino-acid decarboxylase (AADC), 5-hydroxytryptamine, substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), somatostatin (SOM), neuropeptide Y (NPY), leucine-enkephalin, and cholineacetyl transferase (Ch-E). The avidin-biotin complex method was used as the immunohistochemical procedure, and the sections were observed under a light microscope. RESULTS: In the immunohistochemical study, TH-, AADC-, SP-, CGRP-, VIP-, SOM-, NPY-, and Ch-E-positive fibers were seen within the walls of blood vessels in the DRG. This study revealed the existence of a comprehensive perivascular adrenergic, cholinergic, and peptidergic innervation of intraganglionic blood vessels, with a possible role in neurogenic regulation (autoregulation) of intraganglionic circulation. CONCLUSIONS: The presence of perivascular nerve plexuses around intraganglionic microvessels suggests that autonomic nerves play an important role in intraganglionic circulation. |
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Authors:
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Shigeru Kobayashi; Erisa Sabakaki Mwaka; Hisatoshi Baba; Yasuo Kokubo; Takafumi Yayama; Masafumi Kubota; Hideaki Nakajima; Adam Meir |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurosurgery. Spine Volume: 12 ISSN: 1547-5646 ISO Abbreviation: J Neurosurg Spine Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101223545 Medline TA: J Neurosurg Spine Country: United States |
Other Details:
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Languages: eng Pagination: 203-9 Citation Subset: IM |
Affiliation:
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Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Matsuoka, FukuiJapan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / physiology Ganglia, Spinal / blood supply*, physiology Immunohistochemistry Lumbar Vertebrae* Microcirculation* Microvessels / innervation*, physiology* Motor Neurons / physiology Neurons / physiology* Neurotransmitter Agents / metabolism Rats Rats, Wistar Sensory Receptor Cells / physiology |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents |
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