| Microvascular perfusion 1 week and 6 months after myocardial infarction by first-pass perfusion cardiovascular magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 16803939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To characterise the evolution of myocardial perfusion during the first 6 months after myocardial infarction by first-pass perfusion cardiovascular magnetic resonance imaging (CMR) and determine its significance. DESIGN: Prospective cohort design. SETTING: Single-centre study in a teaching hospital in Spain. PATIENTS: 40 patients with a first ST-elevation myocardial infarction, single-vessel disease and thrombolysis in myocardial infarction (TIMI) grade 3 flow (stent in 33 patients) underwent rest and low-dose dobutamine CMR 7 (SD 1) and 184 (SD 11) days after infarction. Microvascular perfusion was assessed at rest by visual assessment and quantitative analysis of first-pass perfusion CMR. Of the 640 segments, 290 segments subtended by the infarct-related artery (IRA) were focused on. RESULTS: Both 1 week and 6 months after infarction, segments with normal perfusion showed more wall thickening, contractile reserve and wall thickness, and less transmural necrosis, p <0.05 in all cases. Of 76 hypoperfused segments at the first week, 47 (62%) normalised perfusion at the sixth month. However, 42 segments (14% of the whole group) showed chronic abnormal perfusion; these segments showed worse CMR indices in the late phase (p<0.05 in all cases). CONCLUSIONS: In patients with an open IRA, more than half of the segments with abnormal perfusion at the first week are normally perfused after six months. First-pass perfusion CMR shows that in a small percentage of segments, abnormal perfusion may become a chronic phenomenon-these areas have a more severe deterioration of systolic function, wall thickness, contractile reserve and the transmural extent of necrosis. |
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Authors:
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V Bodí; J Sanchis; M P López-Lereu; J Núñez; R Sanz; P Palau; C Gómez; D Moratal; F J Chorro; A Llácer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-27 |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 92 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-19 Completed Date: 2006-12-19 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 1801-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Hospital Clínico y Universitario de Valencia, Universidad de Valencia, Valencia, Spain. vicentbodi@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Coronary Circulation / physiology* Diastole Female Humans Magnetic Resonance Angiography Male Microcirculation / physiology Middle Aged Myocardial Infarction / pathology, physiopathology* Myocardium / pathology Necrosis Prospective Studies Systole |
| Comments/Corrections | |
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