Document Detail

Microvascular injury induced by intravascular platelet aggregation. An experimental study.
MedLine Citation:
PMID:  7792557     Owner:  NLM     Status:  MEDLINE    
Microvascular injury due to platelet aggregation was studied in cats for an hour after 1-hour intraaortic infusion of a suspension of collagen fibrils. Haematocrit and numbers of circulating platelets and leukocytes were repeatedly measured in arterial blood and a major cutaneous lymph vessel in the thigh was cannulated for measurement of lymph flow and erythrocyte counts in peripheral lymph. There were seven groups, each of eight cats, viz. normal cats infused with collagen (I) or vehicle (II) and collagen-infused cats which were platelet-depleted--by antiserum (III), or neutrophil-depleted--by anti-serum (IV), or decomplemented--by cobra venom (V), or pretreated with indomethacin--10 mg/kg (VI), or treated with nonimmunized serum (VII). Induced intravascular platelet aggregation reduced the numbers of circulating platelets and leukocytes, and increased haematocrit, lymph flow and numbers of red cells in peripheral lymph. These effects were inhibited by platelet depletion and indomethacin and attenuated by decomplementation and neutrophil depletion. Platelet aggregation was thus shown to induce microvascular injury and increase microvascular permeability, which is partly dependent on complement and neutrophils.
J Vaage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of thoracic and cardiovascular surgery     Volume:  28     ISSN:  0036-5580     ISO Abbreviation:  Scand J Thorac Cardiovasc Surg     Publication Date:  1994  
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0121343     Medline TA:  Scand J Thorac Cardiovasc Surg     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM; S    
Institute of Physiology, University of Oslo, Norway.
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MeSH Terms
Capillary Permeability
Cardiopulmonary Bypass / adverse effects
Complement System Proteins / physiology
Erythrocyte Count
Lymph / physiology
Microcirculation / injuries*
Neutrophils / physiology
Platelet Activation
Platelet Aggregation*
Platelet Count
Reg. No./Substance:
9007-34-5/Collagen; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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