| Microvascular function at the margins of early experimental myocardial infarcts in isolated rabbit hearts. | |
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MedLine Citation:
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PMID: 3759803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Injection of low-viscosity resin was used to identify in situ functional blood vessels at the margins of developing regional myocardial infarcts. The ventral interventricular branch (VIB) of the left coronary artery was occluded for 0-240 min in 20 isolated perfused rabbit hearts. After perfusion fixation with glutaraldehyde, resin was injected into the coronary arteries--that injected into the VIB contained dispersed lead dioxide and that injected into the remainder of the heart contained Fat Red 7B dye. This allowed macroscopic and microscopic identification of functional blood vessels. Following transmural freeze fracture, left ventricles were examined using back-scattered electron imaging in a scanning electron microscope. Close to 60% of capillaries in nonischemic myocardium allowed the passage of resin. Thirty minutes of ischemia produced a hyperemic increase to 80%-90% in the proportion of filled vessels. After 60 min, however, a severe reperfusion defect corresponding to the "no-reflow" phenomenon had developed, with virtually all vessels collapsed and less than 10% functional. Among the structurally normal myocytes adjacent to the infarct margin there was a significant reduction (to 30%-40%) in the proportion of functional capillaries. This was due to groups of dilated vessels which were not accessible to arterial supply. Although these marginal "low-flow" regions were of small volume at any one point in time, they seem likely to contribute to the progression of ischemic necrosis, and are probably nonfunctional due to the compression of their venous drainage traversing the infarct. |
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Authors:
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M D Sage; J B Gavin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Heart and vessels Volume: 2 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 1986 |
Date Detail:
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Created Date: 1986-11-18 Completed Date: 1986-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: JAPAN |
Other Details:
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Languages: eng Pagination: 81-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillaries / physiopathology Coronary Circulation Coronary Vessels / physiopathology Freeze Fracturing Injections, Intra-Arterial Microcirculation / physiopathology* Microscopy, Electron, Scanning Myocardial Infarction / physiopathology* Myocardium / pathology Necrosis Rabbits Resins, Plant / administration & dosage, diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Resins, Plant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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