| Microvascular evidence for a transition zone around a chronic myocardial infarct in the rat. | |
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MedLine Citation:
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PMID: 6671164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Muscle fibers in the transition zone of an infarcted heart are thought to be potentially ischemic during the first 6-9 h following coronary artery occlusion. However, the long-term fate of the muscle fibers at the margin of the necrosis is uncertain. Ischemia implies reduced oxygenation, possibly owing to a reduced capillary supply; thus our objective was to determine whether a region of reduced microvascular supply exists at the margin of a necrosis produced by chronic coronary artery occlusion. Five variables were used to quantitate the capillary supply in the transition zone: C/F (capillary to fiber) ratio, Vf (number of vessels around a fiber), Fv (number of fibers surrounding a vessel), capillary density, and fiber diameter. Infarcts were induced in young male rats by ligating the left coronary artery midway between its origin and the apex of the heart. Five weeks later, the capillary supply in the transition zone was significantly below control values, i.e., significant reductions in C/F, Vf, and Fv were found. This region of reduced capillary supply extended 225-525 microns laterally from the edge of the necrosis. Thus, a narrow transition zone, defined as a region of viable muscle fibers with a subnormal microvascular supply, exists as long as 5 weeks following coronary artery occlusion in the rat. |
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Authors:
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K Przyklenk; A C Groom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 61 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-05-21 Completed Date: 1984-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 1516-22 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillaries / pathology Coronary Vessels / pathology, physiopathology* Male Myocardial Infarction / pathology, physiopathology* Rats Rats, Inbred Strains |
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