Document Detail

Microvascular changes in venous hypertension due to varicose veins after standardized application of Essaven gel--a placebo-controlled, randomized study.
MedLine Citation:
PMID:  11775643     Owner:  NLM     Status:  MEDLINE    
The involvement of the microvascular structure in chronic venous insufficiency (CVI) causes venous hypertensive microangiopathy (VHM), which leads to venous ulceration. VHM is characterized by enlarged and ramified capillaries, increased flux and capillary permeability, edema, and altered function of microlymphatics. TcPO2 is decreased and CO2 increased. This perfusional paradox is caused by hyperperfusion in the deep skin layers with hypoperfusion of superficial nutritional capillaries. Exchanges in the capillary bed are altered. Nutritional skin alterations eventually lead to venous ulceration. Edema is the consequence of increased capillary pressure, reduced clearance, and by an increased exchange surface of capillaries. The aim of this randomized, placebo-controlled study was to evaluate the effect of local treatment with Essaven gel (EG) in 22 subjects with VHM due to severe varicose veins, treated with a single application. Measurements of flux, PO2 and PCO2 in standardized conditions of application indicated a significant decrease of the abnormally increased flux and CO2; PO2 increased in the treatment group. Essaven gel, in comparison with placebo and controls acutely improves the microcirculation in VHM even with a single application.
M R Cesarone; M T De Sanctis; L Incandela; G Belcaro; M Griffin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Angiology     Volume:  52 Suppl 3     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-01     Completed Date:  2002-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S11-6     Citation Subset:  IM    
Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Italy.
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MeSH Terms
Administration, Topical
Double-Blind Method
Drug Combinations
Escin / administration & dosage*,  pharmacology
Fibrinolytic Agents / administration & dosage*,  pharmacology
Heparin / administration & dosage*,  pharmacology
Hypertension / physiopathology*
Microcirculation / drug effects*
Middle Aged
Phospholipids / administration & dosage*,  pharmacology
Skin / blood supply
Varicose Veins / physiopathology*
Reg. No./Substance:
0/Drug Combinations; 0/Fibrinolytic Agents; 0/Phospholipids; 6805-41-0/Escin; 77430-02-5/Essaven Gel; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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