Document Detail


Microvascular adaptations during maturation of striated muscle.
MedLine Citation:
PMID:  7282939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well known that capillary density in striated muscle changes during maturation. Capillary density is an important determinant of tissue oxygen supply, the other principal determinants being capillary erythrocyte flow and capillary hematocrit. The microcirculation of the hamster cremaster muscle was studied at different stages of development. We found that the microcirculation of juvenile animals was characterized by small intercapillary distances, short capillary lengths, and tortuous vessels. During maturation, the capillaries elongated and developed the more "typical" parallel pattern. Capillary density decreased from 1,626 +/- 60 capillaries . mm-3 at 35 days of age to 696 +/- 65 capillaries . mm-3 at 132 days; erythrocyte flow per capillary decreased from 1,441 +/- 135 to 583 +/- 47 micrometers 3 . s-1; and capillary hematocrit decreased from 21.5 +/- 0.7 to 14.6 +/- 0.6%. Concomitant with these decreases, the functional reserve increased; in adult muscles, capillary density could increase by 42%, erythrocyte flow per capillary by 457.2%, and capillary hematocrit by 112.4%, compared with 7.7, 20.3, and 24.1%, respectively, in immature animals. These observations show that age significantly modifies microvascular parameters related to tissue oxygen supply and provides an explanation for some conflicting observations in the literature.
Authors:
I H Sarelius; D N Damon; B R Duling
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  241     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H317-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Capillaries / physiology
Cricetinae
Erythrocytes / physiology
Hematocrit
Male
Mesocricetus
Muscle Development
Muscles / blood supply*
Oxygen Consumption
Regional Blood Flow
Grant Support
ID/Acronym/Agency:
5F05TW02662/TW/FIC NIH HHS; HL-12792/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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