Document Detail

Microtubules cut loose at the cell cortex.
MedLine Citation:
PMID:  22388006     Owner:  NLM     Status:  Publisher    
The ability of the microtubule cystoskeleton to rapidly and locally reorganize itself in response to intra- and extracellular signals is essential to its wide range of functions.  A site of tightly regulated microtubule dynamics-and the major interface between the microtubule cytoskeleton and the extracellular environment-is the cell cortex, where the selective stabilization and destabilization of microtubule plus-ends is required for normal cell division, morphogenesis and migration.  In a recent study, we found that the cortex of Drosophila S2 and D17 cells is coated with the microtubule severing enzyme and plus-end depolymerase, Kat-60, which actively suppresses microtubule growth and stability along the cell edge.  We have proposed that cortical Kat-60 functions by uncapping plus-ends thereby activating another microtubule depolymerase, KLP10A, preloaded onto the end.  The localized destruction of microtubule plus-ends at specific cortical could feed into larger regulatory pathways, such as those in control of the actin cytoskeleton, to influence cell polarization and motility.
David J Sharp; Brian O'Rourke; Dong Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-01
Journal Detail:
Title:  Fly     Volume:  6     ISSN:  1933-6942     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101470897     Medline TA:  Fly (Austin)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Albert Einstein College of Medicine; Bronx, NY USA.
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