Document Detail

Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver.
MedLine Citation:
PMID:  1361125     Owner:  NLM     Status:  MEDLINE    
In order to cast light on the anti-cholestatic and cytoprotective properties of ursodeoxycholic acid (UDCA), intrahepatic transport and secretion of bile salts and biliary phospholipids were investigated by using isolated perfused livers from colchicine-pretreated rats. Administration of taurocholic acid (TCA) after colchicine pretreatment induced marked cholestasis. Tauroursodeoxycholic acid (TUDCA) treatment, in contrast, was associated with maintenance of bile flow, with excretion rates of bile acids and phospholipids similar to those in control animals. Furthermore, TCA-induced cholestasis in colchicine-treated rat livers was clearly decreased by co-administration of TUDCA. Although simultaneous addition of UDCA also showed slight improvement, with or without taurine pre-treatment, biliary bile-salt analysis also showed that cholestasis was markedly remitted as the excretion of taurine-conjugated UDCA was increased. The results suggest that the cytoprotective and anti-cholestatic effects of TUDCA may be linked to action at the intrahepatocyte level, represented by mild detergent effects on organelle lipids and preservation of intracellular transport even under microtubule-dysfunctional conditions. In addition, it was indicated that cytoprotective effects of UDCA may also be exerted after its conjugation with taurine inside hepatocytes.
T Nakai; K Katagiri; M Hoshino; T Hayakawa; T Ohiwa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  288 ( Pt 2)     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-08     Completed Date:  1993-01-08     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  613-7     Citation Subset:  IM    
First Department of Internal Medicine, Nagoya City University, Medical School, Japan.
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MeSH Terms
Aspartate Aminotransferases / metabolism
Bile / secretion*
Cholestasis / physiopathology*
Colchicine / pharmacology*
Microtubules / physiology*
Rats, Inbred Strains
Secretory Rate / drug effects
Taurochenodeoxycholic Acid / pharmacology*
Taurocholic Acid / pharmacology
Ursodeoxycholic Acid / pharmacology
gamma-Glutamyltransferase / metabolism
Reg. No./Substance:
128-13-2/Ursodeoxycholic Acid; 14605-22-2/tauroursodeoxycholic acid; 516-35-8/Taurochenodeoxycholic Acid; 64-86-8/Colchicine; 81-24-3/Taurocholic Acid; EC; EC Aminotransferases

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