Document Detail


Microtubule-Depolymerizing Kinesins.
MedLine Citation:
PMID:  23875646     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from providing tracks for intracellular transport, to supporting movement of cilia and flagella, to segregating chromosomes in mitosis. These functions are facilitated by the organizational and dynamic plasticity of MT networks. An important class of enzymes that alters MT dynamics is the depolymerizing kinesin-like proteins, which use their catalytic activities to regulate MT end dynamics. In this review, we discuss four topics surrounding these MT-depolymerizing kinesins. We provide a historical overview of studies focused on these motors and discuss their phylogeny. In the second half, we discuss their enzymology and biophysics and give an overview of their known cellular functions. This discussion highlights the fact that MT-depolymerizing kinesins exhibit a diverse range of design principles, which in turn increases their functional versatility in cells. Expected final online publication date for the Annual Review of Cell and Developmental Biology Volume 29 is October 06, 2013. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
Authors:
Claire E Walczak; Sophia Gayek; Ryoma Ohi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-17
Journal Detail:
Title:  Annual review of cell and developmental biology     Volume:  -     ISSN:  1530-8995     ISO Abbreviation:  Annu. Rev. Cell Dev. Biol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9600627     Medline TA:  Annu Rev Cell Dev Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Medical Sciences, Indiana University, Bloomington, IN 47405; email: cwalczak@indiana.edu.
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