| Microtia-anotia: A global review of prevalence rates. | |
| | |
MedLine Citation:
|
PMID: 21656661 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: There are few published studies on microtia-anotia frequency. METHODS: Using data from birth defects surveillance programs around the world, we conducted a systematic review on the frequency of microtia-anotia to further explore the differences in prevalence across countries. Ninety-two birth defects surveillance programs were evaluated with a total of 8917 cases of microtia-anotia. We computed the prevalence per 10,000 births for each surveillance program for total cases of microtia-anotia (microtia types I to IV), microtia (types I to III), and anotia (type IV). Prevalence ratios were calculated by large geographic areas, race/ethnicity, and by surveillance methodologies. RESULTS: The overall prevalences were: microtia-anotia, 2.06 (confidence interval [CI], 2.02-2.10); microtia, 1.55 (CI, 1.50-1.60); and anotia 0.36 (CI, 0.34-0.38). Higher prevalences were observed for the Americas, Northern Europe and Asia, among Hispanics and Asians, and among active ascertainment and hospital-based surveillance programs. CONCLUSIONS: We observed marked variation in the prevalence of microtia-anotia across surveillance programs and within countries. These results must be interpreted cautiously as this variability may be explained mainly by differences in surveillance methods. However, given the magnitude of some of the differences, other factors may also be involved. This study contributes to the knowledge of the prevalence of microtia-anotia by providing a critical analysis of the existing data. In addition, it supports the need for a coding system that allows complete phenotype characterization of microtia-anotia, including severity and laterality, as well as for further studies on the variation of its frequency related to race and ethnicity. Birth Defects Research (Part A), 2011. © 2011 Wiley-Liss, Inc. |
| | |
Authors:
|
Daniela Varela Luquetti; Emanuele Leoncini; Pierpaolo Mastroiacovo |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-7 |
Journal Detail:
|
Title: Birth defects research. Part A, Clinical and molecular teratology Volume: - ISSN: 1542-0760 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
|
Division of Craniofacial Medicine, Department of Pediatrics, University of Washington, Seattle, Washington. daniela.luquetti@seattlechildrens.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Epigenomic reprogramming of the developing reproductive tract and disease susceptibility in adulthoo...
Next Document: Observations of cell size dynamics under osmotic stress.