Document Detail


Microstructure and nanomechanical properties in osteons relate to tissue and animal age.
MedLine Citation:
PMID:  21074774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Material property changes in bone tissue with ageing are a crucial missing component in our ability to understand and predict age-related fracture. Cortical bone osteons contain a natural gradient in tissue age, providing an ideal location to examine these effects. This study utilized osteons from baboons aged 0-32 years (n=12 females), representing the baboon lifespan, to examine effects of tissue and animal age on mechanical properties and composition of the material. Tissue mechanical properties (indentation modulus and hardness), composition (mineral-to-matrix ratio, carbonate substitution, and crystallinity), and aligned collagen content (aligned collagen peak height ratio) were sampled along three radial lines in three osteons per sample by nanoindentation, Raman spectroscopy, and second harmonic generation microscopy, respectively. Indentation modulus, hardness, mineral-to-matrix ratio, carbonate substitution, and aligned collagen peak height ratio followed biphasic relationships with animal age, increasing sharply during rapid growth before leveling off at sexual maturity. Mineral-to-matrix ratio and carbonate substitution increased 12% and 6.7%, respectively, per year across young animals during growth, corresponding with a nearly 7% increase in stiffness and hardness. Carbonate substitution and aligned collagen peak height ratio both increased with tissue age, increasing 6-12% across the osteon radii. Indentation modulus most strongly correlated with mineral-to-matrix ratio, which explained 78% of the variation in indentation modulus. Overall, the measured compositional and mechanical parameters were the lowest in tissue of the youngest animals. These results demonstrate that composition and mechanical function are closely related and influenced by tissue and animal age.
Authors:
Jayme Burket; Samuel Gourion-Arsiquaud; Lorena M Havill; Shefford P Baker; Adele L Boskey; Marjolein C H van der Meulen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-11-12
Journal Detail:
Title:  Journal of biomechanics     Volume:  44     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-04-27     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Bone and Bones / physiology
Female
Femur / physiology
Haversian System / physiology*
Microscopy, Atomic Force / methods
Nanotechnology / methods
Osteoporosis / physiopathology
Papio
Spectrum Analysis, Raman / methods
Tensile Strength
Time Factors
Grant Support
ID/Acronym/Agency:
P30 AR046121/AR/NIAMS NIH HHS; P30 AR046121-10/AR/NIAMS NIH HHS; P30-AR046121/AR/NIAMS NIH HHS; P51-RR013987/RR/NCRR NIH HHS; R01 AR041325/AR/NIAMS NIH HHS; R01 AR041325-14/AR/NIAMS NIH HHS; R01 AR041325-19/AR/NIAMS NIH HHS; R01 AR053571/AR/NIAMS NIH HHS; R01 AR053571-04/AR/NIAMS NIH HHS; R01-AR041325/AR/NIAMS NIH HHS; R01-AR053571/AR/NIAMS NIH HHS
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