Document Detail

Microstructural and functional connectivity in the developing preterm brain.
MedLine Citation:
PMID:  21255705     Owner:  NLM     Status:  MEDLINE    
Prematurely born children are at increased risk for cognitive deficits, but the neurobiological basis of these findings remains poorly understood. Because variations in neural circuitry may influence performance on cognitive tasks, recent investigations have explored the impact of preterm birth on connectivity in the developing brain. Diffusion tensor imaging studies demonstrate widespread alterations in fractional anisotropy, a measure of axonal integrity and microstructural connectivity, throughout the developing preterm brain. Functional connectivity studies report that preterm neonates, children and adolescents exhibit alterations in both resting state and task-based connectivity when compared with term control subjects. Taken together, these data suggest that neurodevelopmental impairment following preterm birth may represent a disease of neural connectivity.
Julia Lubsen; Betty Vohr; Eliza Myers; Michelle Hampson; Cheryl Lacadie; Karen C Schneider; Karol H Katz; R Todd Constable; Laura R Ment
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Seminars in perinatology     Volume:  35     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-24     Completed Date:  2011-05-12     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520-8064, USA.
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MeSH Terms
Brain / growth & development*,  pathology,  physiopathology
Brain Diseases / pathology*,  physiopathology*
Cognition Disorders / pathology,  physiopathology
Diffusion Magnetic Resonance Imaging
Electrophysiological Processes / physiology
Follow-Up Studies
Infant, Newborn
Infant, Premature / growth & development*
Interneurons / physiology
Magnetic Resonance Imaging
Oligodendroglia / physiology
Premature Birth / pathology*,  physiopathology*
Risk Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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