| Microstructural development: Organizational differences of the fiber architecture between children and adults in dorsal and ventral visual streams. | |
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MedLine Citation:
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PMID: 20533564 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Visual perceptual skills are basically mature by the age of 7 years. White matter, however, continues to develop until late adolescence. Here, we examined children (aged 5-7 years) and adults (aged 20-30 years) using diffusion tensor imaging (DTI) fiber tracking to investigate the microstructural maturation of the visual system. We characterized the brain volumes, DTI indices, and architecture of visual fiber tracts passing through white matter structures adjacent to occipital and parietal cortex (dorsal stream), and to occipital and temporal cortex (ventral stream). Dorsal, but not ventral visual stream pathways were found to increase in volume during maturation. DTI indices revealed expected maturational differences, manifested as decreased mean and radial diffusivities and increased fractional anisotropy in both streams. Additionally, fractional anisotropy was increased and radial diffusivity was decreased in the adult dorsal stream, which can be explained by specific dorsal stream myelination or increasing fiber compaction. Adult dorsal stream architecture showed additional intra- and interhemispheric connections: Dorsal fibers penetrated into contralateral hemispheres via commissural structures and projection fibers extended to the superior temporal gyrus and ventral association pathways. Moreover, intra-hemispheric connectivity was particularly strong in adult dorsal stream of the right hemisphere. Ventral stream architecture also differed between adults and children. Adults revealed additional connections to posterior lateral areas (occipital-temporal gyrus), whereas children showed connections to posterior medial areas (posterior parahippocampal and lingual gyrus). Hence, in addition to dorsal stream myelination or fiber compaction, progressing maturation of intra- and interhemispheric connectivity may contribute to the development of the visual system. Hum Brain Mapp, 2011. © 2010 Wiley-Liss, Inc. |
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Authors:
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Thomas Loenneker; Peter Klaver; Kerstin Bucher; Janine Lichtensteiger; Adrian Imfeld; Ernst Martin |
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Publication Detail:
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Type: Journal Article Date: 2010-06-09 |
Journal Detail:
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Title: Human brain mapping Volume: 32 ISSN: 1097-0193 ISO Abbreviation: Hum Brain Mapp Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9419065 Medline TA: Hum Brain Mapp Country: United States |
Other Details:
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Languages: eng Pagination: 935-46 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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MR Centre, University Children's Hospital Zurich, Zurich, Switzerland; Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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