Document Detail

Microstructural characteristics of human skin subjected to static versus cyclic pressures.
MedLine Citation:
PMID:  11732826     Owner:  NLM     Status:  MEDLINE    
Pressure ulcers are generally associated with external pressures exceeding internal capillary pressures over bony prominences when the body cannot initiate motor movement to change positions. This investigation evaluated microstructural changes occurring in human skin, in vitro, exposed to static versus cyclic pressures, simulating those recorded for heels of human subjects on various pressure-relief mattresses. Morphological data are reported for tissues exposed to pressure in a bench-scale loading system. Dynamic (cyclic-relief) pressure induced parallel alignments of connective tissue collagen bundles, which themselves became differentially oriented to various degrees perpendicular to the surface of the tissue. Static pressure, with no relief, invariably produced alignment of the collagen bundles of the connective tissue parallel to both one another and to the compressed tissue surface. The precursor to pressure ulcer formation may be microstructural alignment in response to the pressure conditions on tissue.
L E Edsberg; J R Natiella; R E Baier; J Earle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of rehabilitation research and development     Volume:  38     ISSN:  0748-7711     ISO Abbreviation:  J Rehabil Res Dev     Publication Date:    2001 Sep-Oct
Date Detail:
Created Date:  2001-12-04     Completed Date:  2002-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8410047     Medline TA:  J Rehabil Res Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  477-86     Citation Subset:  IM    
Natural and Health Sciences Research Center, Daemen College, Amherst, New York 14226, USA.
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MeSH Terms
Epithelium / anatomy & histology
Pressure Ulcer / pathology*
Skin / anatomy & histology*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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