Document Detail

Microstructural analysis of the involvement of beta-receptors in amphetamine anorexia.
MedLine Citation:
PMID:  6291067     Owner:  NLM     Status:  MEDLINE    
Rats were trained to take food by pushing the door of the pellet dispenser in an operant chamber. Log survivor analysis of the inter-response time frequency distribution was used to determine whether or not an animal was eating, at any time during a thirty minute session. This information was used to compute eating time, eating rate, and the mean length of bouts of eating and gaps between eating bouts. Video-recordings confirmed that the method discriminated eating from not eating with an accuracy of approximately ninety percent. Amphetamine (0.5 mg/kg) significantly reduced total food intake and eating time, and increased gap length; propranolol (5 mg/kg) significantly increased eating time and bout length. Following propranolol pretreatment, amphetamine significantly reduced eating time and bout length but also significantly increased eating rate; as a result there was no significant decrease in total food intake. The possible mediation of these effects by beta-adrenergic and dopaminergic systems is discussed.
P Willner; A Towell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  17     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-62     Citation Subset:  IM    
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MeSH Terms
Amphetamine / pharmacology*
Brain / drug effects*
Conditioning, Operant / drug effects
Eating / drug effects*
Propranolol / pharmacology
Receptors, Adrenergic / drug effects*
Receptors, Adrenergic, beta / drug effects*
Reg. No./Substance:
0/Receptors, Adrenergic; 0/Receptors, Adrenergic, beta; 300-62-9/Amphetamine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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