Document Detail


Microsporidial keratoconjunctivitis caused by Septata intestinalis in a patient with acquired immunodeficiency syndrome.
MedLine Citation:
PMID:  8644819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine and treat a patient with acquired immunodeficiency syndrome (AIDS) who had mildly hyperemic conjunctiva and epithelial keratopathy in both eyes. METHODS: The patient underwent conjunctival biopsy. The specimen was examined by transmission electron microscopy. RESULTS: Septata intestinalis was demonstrated to be the cause of keratoconjunctivitis in the patient. The keratoconjunctivitis resolved after three weeks of therapy with topical fumagillin. No organisms were seen on repeat conjunctival biopsy. CONCLUSIONS: Microsporidial keratoconjunctivitis in patients with AIDS can be caused by S. intestinalis. This condition appears to respond to topical fumagillin.
Authors:
C Y Lowder; J T McMahon; D M Meisler; E M Dodds; L H Calabrese; E S Didier; A Cali
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  121     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-12     Completed Date:  1996-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  715-7     Citation Subset:  AIM; IM; X    
Affiliation:
Division of Ophthalmology, Cleveland Clinic Foundation, OH 44195, USA.
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / drug therapy,  etiology*,  parasitology
Administration, Topical
Adult
Animals
Antiprotozoal Agents / therapeutic use
Biopsy
Conjunctiva / parasitology,  pathology
Cyclohexanes
Epithelium / parasitology,  pathology
Eye Infections, Parasitic / drug therapy,  etiology*,  parasitology
Fatty Acids, Unsaturated / therapeutic use
Feces / parasitology
Humans
Intestinal Diseases, Parasitic / drug therapy,  etiology
Keratoconjunctivitis / drug therapy,  parasitology*
Male
Microsporida / isolation & purification,  ultrastructure
Microsporidiosis / drug therapy,  etiology*,  parasitology
Ophthalmic Solutions
Sesquiterpenes
Chemical
Reg. No./Substance:
0/Antiprotozoal Agents; 0/Cyclohexanes; 0/Fatty Acids, Unsaturated; 0/Ophthalmic Solutions; 0/Sesquiterpenes; 23110-15-8/fumagillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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