Document Detail


Microsporidia evolved from ancestral sexual fungi.
MedLine Citation:
PMID:  18976912     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microsporidia are obligate, intracellular eukaryotic pathogens that infect animal cells, including humans [1]. Previous studies suggested microsporidia share a common ancestor with fungi [2-7]. However, the exact nature of this phylogenetic relationship is unclear because of unusual features of microsporidial genomes, which are compact with fewer and highly divergent genes [8]. As a consequence, it is unclear whether microsporidia evolved from a specific fungal lineage, or whether microsporidia are a sister group to all fungi. Here, we present evidence addressing this controversial question that is independent of sequence-based phylogenetic reconstruction, but rather based on genome structure. In the zygomycete basal fungal lineage, the sex locus is a syntenic gene cluster governing sexual reproduction in which a high mobility group (HMG) transcription-factor gene is flanked by triose-phosphate transporter (TPT) and RNA helicase genes [9]. Strikingly, microsporidian genomes harbor a sex-related locus with the same genes in the same order. Genome-wide synteny analysis reveals multiple other loci conserved between microsporidia and zygomycetes to the exclusion of all other fungal lineages with sequenced genomes. These findings support the hypothesis that microsporidia are true fungi that descended from a zygomycete ancestor and suggest microsporidia may have an extant sexual cycle.
Authors:
Soo Chan Lee; Nicolas Corradi; Edmond J Byrnes; Santiago Torres-Martinez; Fred S Dietrich; Patrick J Keeling; Joseph Heitman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-10-30
Journal Detail:
Title:  Current biology : CB     Volume:  18     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-03     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1675-9     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/FJ008719;  FJ008720;  FJ009106;  FJ009107
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MeSH Terms
Descriptor/Qualifier:
Biological Evolution*
Genes, Mating Type, Fungal*
Genome, Fungal*
Microsporidia / genetics*
Molecular Sequence Data
Synteny*
Grant Support
ID/Acronym/Agency:
AI50113/AI/NIAID NIH HHS; R01 AI050113/AI/NIAID NIH HHS; R01 AI050113-05/AI/NIAID NIH HHS; R21 AI064118/AI/NIAID NIH HHS; R21 AI52792/AI/NIAID NIH HHS
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