| Microsphere distribution in the pancreas of anesthetized rats. Alloxan stimulates the blood flow to all islets whereas glucose only affects the blood perfusion of a subgroup of islets. | |
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MedLine Citation:
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PMID: 8872526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: Islet blood flow stimulation induced by alloxan leads to an increased blood perfusion in all islets, whereas glucose induces a flow increase only in a subgroup of islets. BACKGROUND: The aim of the present study was to investigate if an increased islet blood flow was associated with an enhanced total number of perfused islets, or whether only a subgroup of the islets increased their blood flow. METHODS: For this purpose, the whole pancreatic and islet blood flow was measured with a microsphere technique (4.5 x 10(5) microspheres/kg body wt) in anesthetized Sprague-Dawley rats. Blood flow measurements were made 3 min after an i.v. injection of 1 mL of saline, alloxan (75 mg/kg body wt), or D-glucose (300 mg/mL). RESULTS: Alloxan reduced whole pancreatic blood flow by 50%, but almost doubled islet blood flow. Glucose did not affect whole pancreatic blood flow, but increased islet blood flow 100%. Approximately 10% of the islets in control and glucose-injected rats contained microspheres, compared with about 25% in alloxan-injected rats (P < 0.001). When the islets containing a certain number of microspheres were compared, alloxan induced a homogeneous shift of the curve to the right, i.e., increased the number of islets that contained all amounts of microspheres. Glucose preferentially increased only the fraction of islets containing > or = 3 microspheres. |
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Authors:
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L Jansson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of pancreatology : official journal of the International Association of Pancreatology Volume: 20 ISSN: 0169-4197 ISO Abbreviation: Int. J. Pancreatol. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-01-16 Completed Date: 1997-01-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703511 Medline TA: Int J Pancreatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 69-74 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alloxan
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pharmacology* Animals Blood Glucose / analysis, drug effects Blood Pressure / drug effects Glucose / pharmacology* Islets of Langerhans / blood supply*, drug effects Male Microspheres Pancreas / blood supply*, drug effects Rats Rats, Sprague-Dawley Regional Blood Flow |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 50-71-5/Alloxan; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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