Document Detail

Microscopic structural study of collagen aging in isolated fibrils using polarized second harmonic generation.
MedLine Citation:
PMID:  23224157     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT. Polarization resolved second harmonic generation (PSHG) is developed to study, at the microscopic scale, the impact of aging on the structure of type I collagen fibrils in two-dimensional coatings. A ribose-glycated collagen is also used to mimic tissue glycation usually described as an indicator of aging. PSHG images are analyzed using a generic approach of the molecular disorder information in collagen fibrils, revealing significant changes upon aging, with a direct correlation between molecular disorder and fibril diameters.
Dora Aït-Belkacem; Marie Guilbert; Muriel Roche; Julien Duboisset; Patrick Ferrand; Ganesh Sockalingum; Pierre Jeannesson; Sophie Brasselet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  17     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80506-1     Citation Subset:  IM    
Aix-Marseille Université, Institut Fresnel, CNRS UMR 7249, Ecole Centrale, Marseille, Domaine Universitaire St. Jérôme, 13013 Marseille, France.
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