| Microscopic polyangitis presenting with temporal arteritis and multiple cranial neuropathies. | |
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MedLine Citation:
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PMID: 17379246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis affects vessels of various diameters in various tissues or organs, sometimes associated with neurological complications. A 77-year-old man developed dysphagia, hoarseness, dysgeusia, gait unsteadiness, and right temporalgia; neurological examination revealed multiple cranial neuropathies. Laboratory studies demonstrated severe inflammatory responses, elevation of perinuclear ANCA, and mild proteinuria. Magnetic resonance imaging of the brain showed dural enhancement in the cerebellar tentorium. Biopsy revealed necrotizing glomerulonephritis in the kidney, and temporal arteritis without giant cells in the temporal artery. The patient was diagnosed with microscopic polyangitis presenting with temporal arteritis and multiple cranial nerve involvement, and was treated with predonisolone, after which the symptoms and laboratory data showed improvement. This is the first case of ANCA-associated vasculitis with pathologically verified lesions in the temporal artery as well as in the kidney. Thus, ANCA-associated vasculitis may simultaneously affect large vessels such as temporal artery, as well as microvessels in the kidney, nerves and other organs. |
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Authors:
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Akiyoshi Morinaga; Kenjiro Ono; Kiyonobu Komai; Masahito Yamada |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-03-26 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 256 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-17 Completed Date: 2007-07-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 81-3 Citation Subset: IM |
Affiliation:
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Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Takaramachi 13-1, Kanazawa, Japan. amorinag@med.kanazawa-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies, Antineutrophil Cytoplasmic / analysis* Cranial Nerve Diseases / immunology*, pathology* Giant Cell Arteritis / immunology*, pathology* Humans Magnetic Resonance Imaging / methods Male |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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