| Microscopic lesions of placenta and Doppler velocimetry related to fetal growth restriction. | |
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MedLine Citation:
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PMID: 21153651 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: The purpose of the study was to find an association between the uterine and umbilical arteries blood flow patterns in growth-restricted (FGR) and normal fetuses and placental microscopic lesions. METHODS: Fifty women with prenatally suspected and post-delivery confirmed FGR of singleton fetuses were enrolled in a case-controlled follow-up study from May 2007 to December 2008. Unselected patients with appropriately growing fetuses, matched for gestational age, served as controls. Uterine and umbilical Doppler waveforms were recorded before delivery. RESULTS: Compared with control group with normal Doppler, FGR women with abnormal Doppler velocimetry of uterine and umbilical arteries had more intervillous thrombi (p = 0.01 and p < 0.0001, respectively) and villous infarctions (p = 0.02 and p = 0.0003, respectively). Thickening of the basal membrane and villitis was clearly linked to the FGR (p = 0.006 and p = 0.01). Vasculitis, on the other hand, is linked to normal growth, without affecting Doppler velocities. CONCLUSIONS: Abnormal Doppler may predict hemorrhagic and ischemic placental lesions in FGR pregnancies and may lead to future improvement of the management of current and subsequent pregnancies. |
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Authors:
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Natalija Vedmedovska; Dace Rezeberga; Uldis Teibe; Ivars Melderis; Gilbert G G Donders |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-14 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: - ISSN: 1432-0711 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Obstetrics and Gynaecology, Riga Stradins University, Dzirciema Street 16, Riga, 1013, Latvia, natalyved@apollo.lv. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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