Document Detail


Microscopic colitis. A review.
MedLine Citation:
PMID:  23419063     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Microscopic colitis (MC) is characterized by a triad of watery diarrhea, usually normal colonoscopic findings and typical microscopic findings. Two distinct histological forms of MC have been defined: lymphocytic colitis and collagenous colitis, but overlapping features may be present. The incidence of MC appears to be rising, and in some countries it may account for as much as 10-20% of the cases with non-bloody, watery diarrhea. The cause of MC remains unknown and is likely multifactorial. The pathogenesis is poorly defined, and numerous immunological abnormalities have been reported. MC is commonly associated with autoimmune diseases including celiac disease. Use of various medications, most notably non-steroidal anti-inflammatory agents and proton pump inhibitors, have been etiologically implicated but not firmly established as causative. In imperfect trials, several agents have been reported effective in the treatment of MC; budesonide is the best-studied, and evidence supporting its effectiveness is the most persuasive. In cases of otherwise unexplained watery, non-bloody diarrhea, MC should be considered and colonic biopsied specimens should be taken of normal-appearing mucosa.
Authors:
William R Brown; Shalini Tayal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-19
Journal Detail:
Title:  Journal of digestive diseases     Volume:  -     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Journal of Digestive Diseases © 2013 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Medicine, Denver Health Medical Center and University of Colorado School of Medicine, Denver, Colorado, USA.
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