Document Detail


Microscopic colitis associated with lansoprazole: report of two cases and a review of the literature.
MedLine Citation:
PMID:  17454866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microscopic colitis causes chronic watery diarrhea. Many cases may be induced by medications, and lansoprazole, a commonly used proton-pump inhibitor, has been associated with collagenous colitis and lymphocytic colitis, the two subtypes of microscopic colitis. Two cases of collagenous colitis associated with lansoprazole are reported, both in older female patients, who each developed profuse watery diarrhea within weeks of starting lansoprazole to treat upper digestive disorders. Colonoscopy was normal and biopsies demonstrated typical features of collagenous colitis. There was a rapid clinical improvement upon switching from lansoprazole to rabeprazole, and histological normalization on follow-up biopsies. A review of the literature showed 14 other cases of lansoprazole-related microscopic colitis. There are no reported cases of microscopic colitis associated with other proton-pump inhibitors, suggesting a pathophysiologic mechanism specific to the pharmacology of lansoprazole. Clinicians must be aware of this association when prescribing this medication; when a patient taking lansoprazole develops diarrhea, substituting an alternative proton-pump inhibitor should allow resolution of the diarrhea.
Authors:
Nilesh Chande; David K Driman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  42     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  530-3     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Gastroenterology, University of Western Ontario and London Health Sciences Centre, South St. Hospital, 375 South Street, London, Ontario. Canada. nchande2@uwo.ca
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MeSH Terms
Descriptor/Qualifier:
2-Pyridinylmethylsulfinylbenzimidazoles / adverse effects*
Aged
Colitis, Microscopic / chemically induced*,  pathology
Female
Humans
Proton Pumps / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Proton Pumps; 103577-45-3/lansoprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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