| Microscopic colitis associated with lansoprazole: report of two cases and a review of the literature. | |
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MedLine Citation:
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PMID: 17454866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microscopic colitis causes chronic watery diarrhea. Many cases may be induced by medications, and lansoprazole, a commonly used proton-pump inhibitor, has been associated with collagenous colitis and lymphocytic colitis, the two subtypes of microscopic colitis. Two cases of collagenous colitis associated with lansoprazole are reported, both in older female patients, who each developed profuse watery diarrhea within weeks of starting lansoprazole to treat upper digestive disorders. Colonoscopy was normal and biopsies demonstrated typical features of collagenous colitis. There was a rapid clinical improvement upon switching from lansoprazole to rabeprazole, and histological normalization on follow-up biopsies. A review of the literature showed 14 other cases of lansoprazole-related microscopic colitis. There are no reported cases of microscopic colitis associated with other proton-pump inhibitors, suggesting a pathophysiologic mechanism specific to the pharmacology of lansoprazole. Clinicians must be aware of this association when prescribing this medication; when a patient taking lansoprazole develops diarrhea, substituting an alternative proton-pump inhibitor should allow resolution of the diarrhea. |
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Authors:
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Nilesh Chande; David K Driman |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 42 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
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Languages: eng Pagination: 530-3 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Gastroenterology, University of Western Ontario and London Health Sciences Centre, South St. Hospital, 375 South Street, London, Ontario. Canada. nchande2@uwo.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles
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adverse effects* Aged Colitis, Microscopic / chemically induced*, pathology Female Humans Proton Pumps / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Proton Pumps; 103577-45-3/lansoprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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