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Microscopic Colitis: A Review.
MedLine Citation:
PMID:  25039699     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: In recent years microscopic colitis (MC) has been increasingly diagnosed. This review was performed to evaluate demographic factors for MC and a systematic assessment of available treatment options.
METHOD: PUBMED and Google Scholar were used as search engines with "microscopic colitis" "collagenous colitis" or "lymphocytic colitis" as key words to identify relevant papers published up to December 2013. 248 relevant papers were identified.
RESULTS: The term microscopic colitis (MC) includes lymphocytic colitis (LC) and collagenous colitis (CC). Both have common clinical symptoms but are well defined histopathologically. The clinical course is usually benign but serious complications including death may occur. A peak incidence from 60 to 70 years of age with a female preponderance is observed. Although most cases are idiopathic, associations with autoimmune disorders, such as coeliac disease and hypothyroidism, have been observed, as well as exposure to NSAIDs and proton pump inhibitors.. The incidence and prevalence of microscopic colitis is rising and good quality epidemiological research is needed. Treatment is currently largely based on anecdotal evidence and on results from limited clinical trials of budesonide. Long term follow up of these patients is not well established.
CONCLUSION: The review synthesizes work on the definition of microscopic colitis and the relationship between collagenous and lymphocytic colitis. It reviews the international epidemiology and work on aetiology. In addition it critically considers the efficacy of a range of treatments. This article is protected by copyright. All rights reserved.
Authors:
A Farrukh; Jf Mayberry
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-9
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  -     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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