Document Detail


Microsatellites reveal heterosis in red deer.
MedLine Citation:
PMID:  9569667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fitness consequences of inbreeding and outbreeding are poorly understood in natural populations. We explore two microsatellite-based variables, individual heterozygosity (likely to correlate with recent inbreeding) and a new individual-specific internal distance measure, mean d2 (focusing on events deeper in the pedigree), in relation to two measures of fitness expressed early in life, birth weight and neonatal survival, in 670 red deer calves (Cervus elaphus) born on the Isle of Rum between 1982 and 1996. For comparison, we also analyse inbreeding coefficients derived from pedigrees in which paternity was inferred by molecular methods. Only 14 out of 231 calves (6.1%) had non-zero inbreeding coefficients, and neither inbreeding coefficient nor individual heterozygosity was consistently related to birth weight or neonatal survival. However, mean d2 was consistently related to both fitness measures. Low mean d2 was associated with low birth weight, especially following cold Aprils, in which foetal growth is reduced. Low mean d2 was also associated with low neonatal survival, but this effect was probably mediated by birth weight because fitting birth weight to the neonatal survival model displaced mean d2 as an explanatory variable. We conclude that in the deer population fitness measures expressed early in life do not show evidence of inbreeding depression, but they do show evidence of heterosis, possibly as a result of population mixing. We also demonstrate the practical problems of estimating inbreeding via pedigrees compared with a direct marker-based estimate of individual heterozygosity. We suggest that, together, individual heterozygosity and mean d2, estimated using microsatellites, are useful tools for exploring inbreeding and outbreeding in natural population.
Authors:
T N Coulson; J M Pemberton; S D Albon; M Beaumont; T C Marshall; J Slate; F E Guinness; T H Clutton-Brock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  265     ISSN:  0962-8452     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-26     Completed Date:  1998-05-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  489-95     Citation Subset:  IM    
Affiliation:
Institute of Zoology, Zoological Society of London, Regent's Park, London, UK. t.coulson@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Newborn
Birth Weight
Deer / genetics*,  physiology
Female
Heterozygote
Hybrid Vigor*
Inbreeding
Male
Microsatellite Repeats*
Pedigree
Regression Analysis
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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