| Microsatellites reveal heterosis in red deer. | |
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MedLine Citation:
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PMID: 9569667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fitness consequences of inbreeding and outbreeding are poorly understood in natural populations. We explore two microsatellite-based variables, individual heterozygosity (likely to correlate with recent inbreeding) and a new individual-specific internal distance measure, mean d2 (focusing on events deeper in the pedigree), in relation to two measures of fitness expressed early in life, birth weight and neonatal survival, in 670 red deer calves (Cervus elaphus) born on the Isle of Rum between 1982 and 1996. For comparison, we also analyse inbreeding coefficients derived from pedigrees in which paternity was inferred by molecular methods. Only 14 out of 231 calves (6.1%) had non-zero inbreeding coefficients, and neither inbreeding coefficient nor individual heterozygosity was consistently related to birth weight or neonatal survival. However, mean d2 was consistently related to both fitness measures. Low mean d2 was associated with low birth weight, especially following cold Aprils, in which foetal growth is reduced. Low mean d2 was also associated with low neonatal survival, but this effect was probably mediated by birth weight because fitting birth weight to the neonatal survival model displaced mean d2 as an explanatory variable. We conclude that in the deer population fitness measures expressed early in life do not show evidence of inbreeding depression, but they do show evidence of heterosis, possibly as a result of population mixing. We also demonstrate the practical problems of estimating inbreeding via pedigrees compared with a direct marker-based estimate of individual heterozygosity. We suggest that, together, individual heterozygosity and mean d2, estimated using microsatellites, are useful tools for exploring inbreeding and outbreeding in natural population. |
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Authors:
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T N Coulson; J M Pemberton; S D Albon; M Beaumont; T C Marshall; J Slate; F E Guinness; T H Clutton-Brock |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Proceedings. Biological sciences / The Royal Society Volume: 265 ISSN: 0962-8452 ISO Abbreviation: Proc. Biol. Sci. Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-05-26 Completed Date: 1998-05-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 101245157 Medline TA: Proc Biol Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 489-95 Citation Subset: IM |
Affiliation:
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Institute of Zoology, Zoological Society of London, Regent's Park, London, UK. t.coulson@ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Animals, Newborn Birth Weight Deer / genetics*, physiology Female Heterozygote Hybrid Vigor* Inbreeding Male Microsatellite Repeats* Pedigree Regression Analysis |
| Comments/Corrections | |
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