Document Detail


Microsatellite instability in endometrial polyps.
MedLine Citation:
PMID:  20705379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE(S): To investigate the prevalence of microsatellite instability (MSI) in endometrial polyps and to evaluate whether there are clinical and histopathological parameters associated with this kind of instability.
STUDY DESIGN: Between September 2008 and April 2009, endometrial polyps were collected from 109 patients. MSI was evaluated using the NCI recommended markers BAT25, BAT26, D2S123, D5S346 and D17S250. Histopathological analysis was performed, and clinical information was obtained from patients' records.
RESULT(S): MSI low was detected in 6.4% of the validated samples (7/109). Of the seven MSI that were detected, six were positive for instability at D17S250 and one at D5S346. There were no significant differences between polyps with or without MSI with regard to age, BMI, menarche, parity, miscarriage or menopause; however, MSI was more frequent in polyps with simple hyperplasia without atypia (3/20; 15%). Furthermore, patients with multiple polyps had a marginally but statistically insignificant increase in the frequency of MSI (p<0.07).
CONCLUSION(S): This is the first prospective study of MSI in endometrial polyps using hysteroscopically obtained samples. In a population of 109 patients, MSI was infrequent in endometrial polyps. Although MSI appears to be more frequent in multiple polyps and polyps with simple hyperplasia without atypia, this was not statistically significant.
Authors:
Salete S Rios; Rosângela V Andrade; Rinaldo W Pereira; Nathan R Wall; Khaled Bahjri; Érica Caldas; Larissa Cavalcante; Florêncio Figueiredo
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Publication Detail:
Type:  Journal Article     Date:  2010-08-11
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  153     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-02-24     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Molecular Pathology Post-graduated Program, University of Brasilia, Brasilia, DF, Brazil. saleterios@ig.com.br
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MeSH Terms
Descriptor/Qualifier:
Endometrial Neoplasms / genetics*,  pathology
Female
Humans
Microsatellite Instability*
Middle Aged
Polyps / genetics*,  pathology
Uterine Diseases / genetics*,  pathology
Grant Support
ID/Acronym/Agency:
L60 MD002849-01/MD/NIMHD NIH HHS; L60 MD002849-02/MD/NIMHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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