Document Detail

Microsatellite diversity delineates genetic relationships of Shia and Sunni Muslim populations of Uttar Pradesh, India.
MedLine Citation:
PMID:  20067368     Owner:  NLM     Status:  MEDLINE    
In this study we characterize the genetic diversity and relationships between the Shia and Sunni Muslim populations of North India and geographically targeted neighboring and global populations. We examined a number of parameters of population genetic and forensic interest based on the allele frequencies from 15 autosomal STR loci (D8S1179, D21S11, D7S820, CSF1PO, D19S433, VWA, TPOX, D18S51, D3S1358, THO1, D13S317, D16S539, D2S1338, D5S818, and FGA). All the studied loci were consistent with Hardy-Weinberg equilibrium, except loci D18S51 and FGA for both Muslim populations, even after applying the Bonferroni correction. The combined power of exclusion and combined power of discrimination values for all 15 STR loci were 0.9999 and >0.99999, respectively, in both Muslim populations. Gene diversity values ranged from 0.6784 (TPOX) to 0.9027 (FGA) for Shia Muslims and from 0.7152 (CSF1PO) to 0.9120 (D18S51) for Sunni Muslims. The observed heterozygosity (H(o)) ranged from 0.5833 (D18S51) to 0.8595 (VWA) in Shia Muslims and from 0.6818 (CSF1PO) to 0.8333 (D21S11) in Sunni Muslims and was lower than the expected heterozygosity (H(e)) for 11 out of the 15 STRs typed. We analyzed the genetic affinities of the Shia and Sunni Muslim populations with their geographically closest neighboring North Indian, Middle Eastern, East Asian, and European populations using distance-based methods, including neighbor-joining trees and multidimensional scaling. In addition, we estimated the genetic contribution of the putative parental populations included in the analysis to the Shia and Sunni Muslim gene pool using admixture analysis. Although we observed a certain degree of genetic contribution from Iran to both Muslim populations, the results of the phylogenetic analyses based on autosomal STRs suggest genetic relatedness with some of the geographically closest neighboring Hindu religious populations.
Muthukrishnan Eaaswarkhanth; Bhawna Dubey; Poorlin Ramakodi Meganathan; Sabahat Noor; Ikramul Haque
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human biology     Volume:  81     ISSN:  1534-6617     ISO Abbreviation:  Hum. Biol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2010-01-13     Completed Date:  2010-04-15     Revised Date:  2011-04-18    
Medline Journal Info:
Nlm Unique ID:  0116717     Medline TA:  Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-45     Citation Subset:  IM    
National DNA Analysis Center, Central Forensic Science Laboratory, 30 Gorachand Road, Kolkata 700 014, West Bengal, India.
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MeSH Terms
Asian Continental Ancestry Group / genetics*
Ethnic Groups / genetics*
Gene Frequency
Genetic Variation / genetics*
Genetics, Population / methods*
India / ethnology
Microsatellite Repeats / genetics*

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