| Microsatellite distribution and indication for locoregional therapy in small hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 15578688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intrahepatic disease recurrence is observed frequently after locoregional therapies for patients with hepatocellular carcinoma (HCC). However, the indication for locoregional therapy is still unclear. To clarify the indication for locoregional therapy for small HCC tumors, the authors measured the distance of microsatellites from the main tumor and analyzed the relation between this distance and clinicopathologic factors. METHODS: The authors retrospectively analyzed 100 patients with small HCC tumors (</= 5 cm in dimension) treated by curative hepatectomy. A microsatellite was defined as invasion into the portal vein or intrahepatic metastasis, and the distance from the main tumor to the most distant microsatellite was determined under light microscopy. The current study investigated the relation between microsatellite distance (0 mm if none present, </= 5 mm, and > 5 mm) and clinicopathologic factors, as well as overall and disease-free survival rates after hepatectomy. RESULTS: Of the 100 patients, 46 had microsatellites with a mean distance of 9.9 mm (median, 5.0 mm). Of the clinicopathologic factors investigated, tumor grade and preoperative alpha-fetoprotein level significantly correlated with the presence of a microsatellite. Tumor size and distance to the microsatellite were significantly correlated. All but 1 tumor associated with a microsatellite distance > 5 mm was a high-grade tumor > 25 mm in greatest dimension. The overall survival rate of patients with a microsatellite distance of > 5 mm was lower than that of patients with a microsatellite distance < 5 mm. CONCLUSIONS: Locoregional therapy, including limited resection and ablation therapies, was appropriate for patients with low-grade HCC tumors or with tumors < 25 mm in diameter. |
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Authors:
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Atsushi Sasaki; Seiichiro Kai; Yukio Iwashita; Seitaro Hirano; Masayuki Ohta; Seigo Kitano |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Cancer Volume: 103 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 299-306 Citation Subset: AIM; IM |
Copyright Information:
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(c) 2004 American Cancer Society. |
Affiliation:
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Department of Surgery I, Oita University Faculty of Medicine, Oita, Japan. sasakia@med.oita-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Analysis of Variance Biopsy, Needle Carcinoma, Hepatocellular / mortality*, pathology*, therapy Chemoembolization, Therapeutic Cohort Studies Disease-Free Survival Female Hepatectomy / methods Humans Immunohistochemistry Liver Neoplasms / mortality*, pathology*, therapy Male Microsatellite Repeats Middle Aged Multivariate Analysis Neoplasm Invasiveness / pathology* Neoplasm Staging Probability Prognosis Retrospective Studies Risk Assessment Sensitivity and Specificity Survival Analysis Treatment Outcome Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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