Document Detail

Micropuncture measurements of interstitial fluid pressure in normal and inflamed gingiva in rats.
MedLine Citation:
PMID:  1403583     Owner:  NLM     Status:  MEDLINE    
Interstitial fluid pressure (IFP) in normal and inflamed gingiva of rats was measured by sharpened glass capillaries (diameter 2-4 microns) connected to a servocontrolled counterpressure system ad modum Wiederhielm. Gingival inflammation was induced by a steel ligature placed unilaterally around the first maxillary molar. After 8 weeks, the ligature was removed and measurements of IFP in normal and experimentally inflamed gingiva were made by puncture through the intact oral epithelium. Average IFP on the control side was 3.5 mm Hg in free, and 7.4 mm Hg in attached gingiva. Compared to the control side, IFP on the experimental inflamed side was elevated significantly (p less than 0.05) both in free and attached gingiva. In the ligated inflamed side IFP in free gingiva averaged 6.7 mm Hg, whereas in attached gingiva it showed a mean value of 10.4 mm Hg. Histological examinations showed a dense infiltrate of inflammatory cells in the connective tissue, while the contralateral control side showed normal features of epithelial and connective tissue. The present finding of increased IFP in the inflamed gingiva may in theory contribute to augmented crevicular fluid flow during inflammation.
M Fjaertoft; A C Johannessen; K J Heyeraas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of periodontal research     Volume:  27     ISSN:  0022-3484     ISO Abbreviation:  J. Periodont. Res.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-10-30     Completed Date:  1992-10-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0055107     Medline TA:  J Periodontal Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  534-8     Citation Subset:  D; IM    
Dep. of Physiology, University of Bergen, Norway.
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MeSH Terms
Blood Pressure
Capillary Permeability
Extracellular Space
Gingiva / blood supply,  physiology*
Gingival Crevicular Fluid*
Gingivitis / physiopathology*
Hydrostatic Pressure
Rats, Sprague-Dawley

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