Document Detail

Microprocessor controlled movement of solid colonic content using sequential neural electrical stimulation.
MedLine Citation:
PMID:  11889065     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Invoked peristaltic contractions and movement of solid content have not been attempted in normal canine colon. The purpose of this study was to determine if movement of solid content through the colon could be produced by microprocessor controlled sequential stimulation.
METHODS: The study was performed on six anaesthetised dogs. At laparotomy, a 15 cm segment of descending colon was selected, the proximal end closed with a purse string suture, and the distal end opened into a collecting container. Four sets of subserosal stimulating electrodes were implanted at 3 cm intervals. The segment of bowel was filled with a mixture of dog food and 50 plastic pellets before each of 2-5 random sessions of non-stimulated or stimulated emptying. Propagated contractions were generated using microprocessor controlled bipolar trains of 50 Hz rectangular voltage having 20 V (peak to peak) amplitude, 18 second stimulus duration, and a nine second phase lag between stimulation trains in sequential electrode sets.
RESULTS: Electrical stimulation using the above mentioned parameters resulted in powerful phasic contractions that closed the lumen. By phase locking the stimulation voltage between adjacent sets of electrodes, propagated contractions could be produced in an aboral or orad direction. The number of evacuated pellets during the stimulation sessions was significantly higher than during the non-stimulated sessions (p<0.01).
CONCLUSIONS: Microprocessor controlled electrical stimulation accelerated movement of colonic content suggesting the possibility of future implantable colonic stimulators.
M A Amaris; P Z Rashev; M P Mintchev; K L Bowes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  50     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-12     Completed Date:  2002-04-23     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  475-9     Citation Subset:  AIM; IM    
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Colon / physiology*
Electric Stimulation / methods
Gastric Emptying
Gastrointestinal Motility / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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