Document Detail


Microporation and 'iron'tophoresis for treating iron deficiency anemia.
MedLine Citation:
PMID:  23187864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Iontophoretic mediated transdermal delivery of ferric pyrophosphate (FPP) in combination with microneedle pretreatment was investigated as a potential treatment for iron deficiency anemia (IDA).
METHODS: In vitro transdermal delivery studies were performed using hairless rat skin and pharmacodynamic studies were performed in hairless anemic rat model. The hematological and biochemical parameters like hemoglobin, hematocrit and % serum transferrin were monitored in rats at healthy, anemic condition and post treatment. Micropores created by the microneedles were visualized in histological skin sections after staining with hemotoxylin and eosin. The recovery of micropores was investigated in vivo by measuring Transepidermal water loss (TEWL) at different time points.
RESULTS: The passive, microneedle and iontophoresis mediated delivery did not lead to significant improvement in hematological and biochemical parameters in anemic rats, when used individually. When iontophoresis (0.15 mA/cm(2) for 4 hours) was combined with microneedle pretreatment (for 2 min), therapeutically adequate amount of FPP was delivered and there was significant recovery of rats from IDA.
CONCLUSIONS: Microneedle and iontophoresis mediated delivery of iron via transdermal route could be developed as a potential treatment for IDA. The transdermal controlled delivery of iron could become a potential, safe and effective alternative to parenteral iron therapy.
Authors:
Naresh Modepalli; Seongbong Jo; Michael A Repka; S Narasimha Murthy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-28
Journal Detail:
Title:  Pharmaceutical research     Volume:  30     ISSN:  1573-904X     ISO Abbreviation:  Pharm. Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-08-01     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  889-98     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Anemia, Iron-Deficiency / blood,  drug therapy*,  pathology
Animals
Diphosphates / administration & dosage*,  therapeutic use
Drug Delivery Systems / instrumentation*
Erythrocytes / drug effects,  pathology
Iontophoresis / instrumentation*
Iron / administration & dosage*,  therapeutic use
Male
Needles
Rats
Rats, Hairless
Grant Support
ID/Acronym/Agency:
HD061531A/HD/NICHD NIH HHS; R03 HD061531/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Diphosphates; E1UOL152H7/Iron; QK8899250F/ferric pyrophosphate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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