Document Detail

Microperimetry as a routine diagnostic test in the follow-up of retinal vein occlusion?
MedLine Citation:
PMID:  21874344     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In the follow-up of retinal vein occlusions, a patient's subjective change in vision frequently cannot be confirmed by objective measurements. Furthermore, contradictory results of OCT and distance visual acuity give the impression that current routine diagnostic tests might not be satisfying for patients with retinal vein occlusions. This prospective case series analyses the value of microperimetry as a routine diagnostic test in the follow-up of patients with retinal vein occlusions during therapy.
METHODS: In a prospective case series, we tested microperimetry as a functional measure in comparison to distance visual acuity, reading ability, and OCT, on 13 patients treated for central or branch retinal vein occlusions. Treatment consisted of intravitreal bevacizumab injections combined with panretinal laser coagulation in cases of peripheral ischemia. If macular edema persisted, bevacizumab injection was repeated, or instead of this intravitreal triamcinolone or focal laser coagulation was applicated. Follow-up ranged from 6-14 months. An interim analysis was performed for the 6-month follow-up.
RESULTS: In the branch retinal vein occlusion group, the average of the retinal thickness measured by OCT was 502.22 μm (±SD 217.75 μm) at baseline and changed to 396.38 ± 154.38 at the 6-month follow-up (p = 0.121). Mean distance visual acuity stayed similar to the study entrance with 0.41 ± 0.34 at the 6-month follow-up (p = 0.944) Mean reading ability improved to 0.51 ± 0.52 at the 6-month follow-up but was not statistically significant (p = 0.435). The mean light sensitivity of microperimetry improved from baseline to the 6-month follow-up: the 40-points group improved from 8.62 ± 5.69 dB to 10.98 ± 5.42 (p = 0.060) and the 8-points group from 6.27 dB to 9.6 dB (p = 0.07) but missed statistical significance. The sector group showed in contrast to this an improvement from 6.02 ± 5.71 dB to 9 ± 6.07 dB (p = 0.025), which was statistically significant. Changes in the central vein occlusion group were not statistically significant but changes for both groups together showed statistical significance.
CONCLUSIONS: In the present case series, microperimetry was more convenient to detect, even the subtle functional changes during the disease course of branch retinal vein occlusions than distance and reading visual acuity. This indicates that microperimetry could be a possible valuable tool in the follow-up of branch retinal vein occlusions.
Sibylle Winterhalter; Anja Lux; Anna Karina Maier; Clara Scholz; Florian M A Heussen; Klaudia K Huber; Antonia M Joussen
Related Documents :
8957334 - Psoralen plus uva protocol for compositae photosensitivity.
10894974 - Topical colchicine therapy for actinic keratoses.
3525264 - Response of solitary psoriatic plaques to experimental application of podophyllotoxin.
24585424 - Intravitreal bevacizumab combined with grid photocoagulation in recurrent macular edema...
10615984 - A comparison of short- and long-term intravenous antibiotic therapy in the postoperativ...
21309934 - A retrospective analysis of benzodiazepine sedation vs. propofol anaesthesia in 252 pat...
Publication Detail:
Type:  Journal Article     Date:  2011-08-27
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  250     ISSN:  1435-702X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-08     Completed Date:  2012-04-16     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  175-83     Citation Subset:  IM    
Department of Ophthalmology, University of Berlin, Charité Virchowklinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angiogenesis Inhibitors / administration & dosage
Antibodies, Monoclonal, Humanized / administration & dosage
Diagnostic Tests, Routine
Follow-Up Studies
Glucocorticoids / administration & dosage
Intravitreal Injections
Laser Coagulation
Prospective Studies
Retinal Vein Occlusion / diagnosis*,  drug therapy,  physiopathology
Scotoma / diagnosis*,  drug therapy,  physiopathology
Tomography, Optical Coherence
Triamcinolone Acetonide / administration & dosage
Vascular Endothelial Growth Factor A / antagonists & inhibitors
Visual Acuity / physiology
Visual Field Tests*
Visual Fields*
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 0/Glucocorticoids; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V/bevacizumab; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Development of a surgical approach for a wide-view suprachoroidal retinal prosthesis: evaluation of ...
Next Document:  Association between photoreceptor integrity and visual outcome in diabetic macular edema.