| Micropatterns of propagation. | |
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MedLine Citation:
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PMID: 16646586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alterations in microscopic conduction could contribute to microreentry and arrhythmogenesis in pathological settings. This chapter reviews microconduction in the ventricular myocardium. Gap junctions play a significant role in longitudinal and transverse propagation of the action potential wavefront in the ventricle. Studies of microscopic conduction in patterned cultures of neonatal rodent myocytes have provided novel insights into the role of gap junctions, the effects of uncoupling versus altered excitability, and the contribution of discontinuities and branching. Decreased gap junctional coupling can contribute to slowing of conduction and development of unidirectional block. However, in the setting of structural inhomogeneities and unbalanced current source and load, decreased coupling can, at times, improve conduction and be 'anti-arrhythmic,' attesting to the complexity of intercellular coupling as a therapeutic target. Genetically engineered mouse models of Cx43 depletion demonstrate slow conduction and arrhythmogenesis that appears to be reentrant in nature. Studies in these models provide novel insights into the contribution of gap junctions to impulse propagation and arrhythmogenesis in the intact heart. Overall, gap junction expression, distribution and heterogeneity are important contributors to microscopic conduction, and alterations in any of these can contribute to the development of an arrhythmogenic substrate in pathological states. |
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Authors:
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Peter J Lee; Steven M Pogwizd |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in cardiology Volume: 42 ISSN: 0065-2326 ISO Abbreviation: Adv Cardiol Publication Date: 2006 |
Date Detail:
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Created Date: 2006-05-01 Completed Date: 2006-07-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0270063 Medline TA: Adv Cardiol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 86-106 Citation Subset: IM |
Affiliation:
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University of Illinois at Chicago, 60612-7323, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Animals Arrhythmias, Cardiac / physiopathology Cells, Cultured Connexins / genetics, physiology Fatty Acids, Monounsaturated / pharmacology Gap Junctions / metabolism, physiology* Gene Deletion Heart / physiology* Humans Mice Mice, Knockout Tetrodotoxin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Connexins; 0/Fatty Acids, Monounsaturated; 2091-29-4/palmitoleic acid; 4368-28-9/Tetrodotoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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