| Microparticles, vascular function and hypertension. | |
| | |
MedLine Citation:
|
PMID: 20051854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: To summarize the potential role of microparticles in hypertension and in cardiovascular diseases. Microparticles are submicron vesicles shed from the membrane in response to cell activation or apoptosis. Microparticles of different cellular origins are found in the plasma of healthy individuals and their circulating levels augment in patients with cardiovascular diseases. RECENT FINDINGS: Recent studies demonstrate that circulating levels of microparticles originating from endothelial cells, which represent a small fraction of the overall pool of plasma microparticles, augment with increased endothelial dysfunction in patients with cardiovascular diseases. Therefore, endothelial microparticles constitute an emerging surrogate marker of endothelial dysfunction, with potential prognostic value for major adverse events in patients with cardiovascular diseases. In addition, microparticles of endothelial and other cellular origins are also potential biological effectors in inflammation, vascular injury, angiogenesis and thrombosis. SUMMARY: In summary, circulating endothelial microparticles may serve not only as an index of arterial damage but also as a trigger of vascular repair. |
| | |
Authors:
|
Chantal M Boulanger |
Related Documents
:
|
12690904 - Ascorbic acid does not improve endothelium-dependent flow-mediated dilatation of the br... 19390244 - Link between coagulation abnormalities and microcirculatory dysfunction in critically i... 16214034 - Oxypurinol improves coronary and peripheral endothelial function in patients with coron... 22135674 - Atherogenic ω-6 lipids modulate ppar- egr-1 crosstalk in vascular cells. 2128194 - Enhancement of the endothelial production of prostacyclin by inhibitors of protein synt... 9566114 - An investigation into the composition of products evolved during heating of hot melt ad... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current opinion in nephrology and hypertension Volume: 19 ISSN: 1473-6543 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-10 Completed Date: 2010-04-30 Revised Date: 2013-05-02 |
Medline Journal Info:
|
Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 177-80 Citation Subset: IM |
Affiliation:
|
INSERM U970, Paris Cardiovascular Research Center-PARCC, Paris, France. Chantal.boulanger@inserm.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Vessels / physiopathology* Cardiovascular Diseases / physiopathology* Cell-Derived Microparticles / physiology* Endothelium, Vascular / pathology Humans Hypertension / physiopathology* Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Essential hypertension and risk of nephropathy: a reappraisal.
Next Document: Management of coexisting cataract and glaucoma.