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Microparticle release in remote ischemic conditioning mechanism.
MedLine Citation:
PMID:  22886414     Owner:  NLM     Status:  Publisher    
Background: Remote ischemic conditioning (RCond) induced by short periods of ischemia and reperfusion of an organ or tissue before myocardial reperfusion is an attractive strategy of cardioprotection in the context of acute myocardial infarction. Nonetheless, its mechanism remains unknown. A humoral factor appears to be involved, although its identity is currently unknown. We hypothesized that the circulating microparticles (MPs) are the link between the remote tissue and the heart. Methods: MPs from rats and healthy human undergoing RCond were characterized. In rats, RCond was induced by 10 min of limb ischemia. In humans, RCond was induced by three cycles of 5 min inflation and 5 min deflation of a blood-pressure cuff. In the second part of the study, rats underwent 40 min myocardial ischemia followed by 2 hours of reperfusion. Infarct size was measured and compared among three groups of rats: (1) myocardial infarction alone (MI) (n=6); (2) MI+RCond started 20 min after coronary ligation (n=6); (3) MI+injection of RCond-derived rat MPs (MI+MPs) (n=5). Results: MPs from endothelial cells (CD54+ and CD146+ for rats and humans, respectively) and procoagulant MPs (Annexin V+) markedly increased after RCond, both in rats and humans. RCond reduced infarct size (24.4±5.9% in MI+RCond vs. 54.6±4.7% in MI alone, P<0.01). Infarct size did not decrease in MI+MPs compared to MI alone (50.2±6.4% vs. 54.6±4.7%, not significantly different). Conclusion: RCond increased endothelium-derived and procoagulant MPs in both rats and humans. However, MP release did not appear to be the biological vector of RCond.
Julien Jeanneteau; Pierre Hibert; Maria Carmen Martinez; Simon Tual-Chalot; Sophie Tamareille; Alain Furber; Ramaroson Andriantsitohaina; Fabrice Prunier
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-10
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Service de Cardiologie, CHU d'Angers, UPRES 3860, Protection et Remodelage du myocarde, UFR Sciences médicales, Université d'Angers, France.
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